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combination of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin hydrochloride (HCl), a biguanide indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus ( 1) Limitations of Use: Not for the treatment of type 1 diabetes --- webmd com drugs 2 drug-159466 janumet-xr-oral detailsmedbroadcast com drug getdrug janumet-xrSee full list on drugs com Janumet XR side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling) Janumet XR: This is a combination medication that contains 2 active ingredients: sitagliptin and metformin They are used together, along with diet and exercise, to improve blood glucose (sugar) levels for adults with type 2 diabetes Sitagliptin – metformin may be used in 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