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Praziquantel – 50 Years of Research Dr Andreas Waechtler, Dr Bertram Cezanne, Dr David Maillard, Dr Rui Sun, Shaofang Wang, Jihua Wang, Dr Achim Harder , In memory of Dr Andreas E F Wächtler (1951–2021), who has been involved in praziquantel research for nearly 20 years of his career as a chemist at Merck KGaA What is praziquantel (PZQ)? Nov 1, 2022 · Praziquantel (PZQ) is a pyrazino-isoquinolein derivative from the thioxantonic group with a broad anthelmintic spectrum [1] and has been used successfully in most treatments of humans infected with trematodes and cestodes (e g , schistosomiasis, taeniasis, cysticercosis) Tested in clinical development under the responsibility of Merck, arpraziquantel contains the pharmacologically active enantiomer of praziquantel It is a 150mg dispersible tablet The prototype of its pediatric formulation was developed by Astellas in Japan and further optimized by Merck in Germany The manufacturing process served to produce Dec 15, 2023 · EMA assessed arpraziquantel under the EU-M4all procedure for high-priority medicines intended for use in countries outside the European Union; Merck is committed to contribute to the elimination of schistosomiasis as a public health problem by 2030 Dec 2, 2022 · European Medicines Agency (EMA) Validates Application for Arpraziquantel to Treat Schistosomiasis in Preschool-Aged Children Merck and the Pediatric Praziquantel Consortium, today announced that the EMA has validated for review the application for arpraziquantel for the treatment of schistosomiasis in preschool chemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 202300140--- thelancet com journals laninf article PIIS1473-3099(23)00059-2 fulltextSchistosomiasis, endemic in 78 low-income and middle-income countries, is the second most serious tropical disease after malaria Globally, more than 250 million people live with schistosomiasis and 779 million are at risk, resulting in an annual burden of 1·4–3·3 million disability-adjusted life-years 1 Schistosomiasis is one of ten neglected tropical diseases listed as a public health Mar 6, 2023 · We show that the efficacy and safety profile of arpraziquantel is similar to that of praziquantel , and arpraziquantel has improved palatability compared with praziquantel Our findings support the potential first-line use of arpraziquantel for preschool-aged children with schistosomiasis Opisthorchis felineus is widespread in Russia, Kazakhstan and Eastern European countries Praziquantel (PZQ) is the drug of choice for the treatment of opisthorchiasis, but the effects of this drug on O felineus are poorly studied Merck is designated as the future Marketing Authorization Holder for African countries Derived from praziquantel, the standard of care treatment developed in the 1970s, arpraziquantel is tailored to meet the needs of preschool-aged children suffering from schistosomiasis This group of approximately 50 million patients currently lacks a --- sciencedirect com science article pii S0166685122000858Who invented praziquantel? Introduction Praziquantel (PZQ) is an essential medicine for the treatment of schistosomiasis (Bilharzia), 1 a disease of poverty that afflicts ∼250 million people worldwide 2 The use and continued efficacy of PZQ is integral to the WHO roadmap of interventions to control schistosomiasis morbidity and to eliminate the disease as a public health problem by 2030 3 WHO estimates that at --- prnewswire com the-european-medicines-agency-ema-validated-regulatory Praziquantel is an anthelmintic medication used to treat parasitic worm infections such as schistosomiasis, clonorchiasis, and opisthorchiasis Brand Names Biltricide Generic Name Praziquantel DrugBank Accession Number DB01058 Background Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad One in 30 people (∼200 million people worldwide) are infected by schistosomiasis, a predominantly African disease, which kills more than 200 000 people each year Given our ongoing interest in neglected diseases and drugs for their treatment, we provide herein the first comprehensive and detailed summary of the chemistry and biology of the chemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 202300154--- merckgroup com global-health-ema-validation-arpraziquantel-02-12-2022 Who should take praziquantel? --- merckgroup com en news arpraziquantel-ema-response-15-12-2023 htmlThe Pediatric Praziquantel Consortium is an international not-for-profit partnership that aims to reduce the global disease burden of schistosomiasis by addressing the medical needs of infected What is arpraziquantel? Apr 3, 2023 · This review summarizes the complex pharmacology of praziquantel and the mode of action on the molecular level, which has recently been elucidated Moreover, it provides an overview of the synthesis routes for large scale preparation of the racemate and the current development of ( R )- praziquantel in the Pediatric Praziquantel Consortium Mar 6, 2023 · The recommendation in earlier guidelines to provide school-aged children (aged 6–15 years) and adults at high risk with a single annual dose of praziquantel has now been extended to cover all age groups older than 2 years WHO WHO guideline on control and elimination of human schistosomiasis Praziquantel (PZQ) is a pyrazino-isoquinolein derivative from the thioxantonic group with a broad anthelmintic spectrum [1] and has been used successfully in most treatments of humans infected with trematodes and cestodes (e g , schistosomiasis, taeniasis, cysticercosis) --- sciencedirect com science article pii S092485791500103XPeople also askgo drugbank com drugs DB01058chemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 201000202Nov 16, 2021 · Press Releases Merck and the Pediatric Praziquantel Consortium today announced that the pivotal Phase III trial for arpraziquantel, a potential new treatment option for the neglected tropical disease schistosomiasis, has met the primary endpoint of clinical cure in children 3 months to 6 years of age