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    Patient information What are the possible side effects of PREMARIN ? Side effects are grouped by how serious they are and how often they happen when you are treated Serious, but less common side effects include: • Heart attack • Stroke • Blood clots • Dementia • Breast --- pfizermedicalinformation com premarin-intravenousPREMARIN® (conjugated estrogens) Medication Guide Patient information 17 PATIENT COUNSELING INFORMATION See FDA-approved patient labeling (Patient Information) 17 1 Vaginal Bleeding Inform postmenopausal women of the importance of reporting vaginal bleeding to their healthcare provider as soon as possible [see Warnings Pfizer : Attn: Premarin , 66 Hudson Boulevard East, New York, NY 10001-2192, --- pfizer com IMPORTANT SAFETY INFORMATION AND INDICATION Using estrogen alone may increase your chance of getting cancer of the uterus (womb) --- pfizermedicalinformation com premarinSearch Medical Information Pfizer Medical Information - US is a website that provides comprehensive and reliable information on Pfizer products, including PREMARIN, a medication used to treat menopausal symptoms You can find detailed descriptions, dosage forms, indications, safety warnings, and more on this website --- premarin com--- pfizer com products product-detail premarinHow should I take PREMARIN? • Take one PREMARIN tablet at the same time each day • If you miss a dose, take it as soon as possible If it is almost time for your next dose, skip the missed dose and go back to your normal schedule Do not take 2 doses at the same time •Each Premarin Intravenous (conjugated estrogens, USP) for injection package provides 25 mg vial of conjugated estrogens, USP, in dry form for intravenous or intramuscular use This product's label may have been updated For current full prescribing information, please visit --- pfizer com LAB-0518-4 0 PREMARIN Vaginal Cream is a medicine that contains a mixture of estrogen hormones What is PREMARIN Vaginal Cream used for? PREMARIN Vaginal Cream is used after menopause to: • Treat menopausal changes in and around the vagina --- pfizermedicalinformation com premarin dosage-admin PREMARIN Vaginal Cream is a cream that you place in your vagina with the applicator provided with the cream Take the dose recommended by your healthcare provider and talk to him or her about how well that dose is working for you PREMARIN therapy should be initiated and maintained with the lowest effective dose to achieve clinical goals Female hypogonadism: 0 3 mg or 0 625 mg daily, administered cyclically (e g , three weeks on and one week off) --- pfizermedicalinformation com patient premarin medguidePREMARIN® (conjugated estrogens) What are the possible side effects of PREMARIN? Patient information What are the possible side effects of PREMARIN? Side effects are grouped by how serious they are and how often they happen when you are treated Serious, but less common side effects include: • Heart attack • Stroke • Blood clots • Dementia • Breast--- pfizermedicalinformation com patient premarin how-should-i-take-premarin--- pfizermedicalinformation com premarin warningsPay for Premarin prescription and mail copy of original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: Pfizer, Attn: Claims Processing Department, IQVIA, Inc , 77 Corporate Drive, Bridgewater, NJ 08807 Be sure to include a copy of the front of your co-pay card, your name, and mailing address PREMARIN ® (conjugated estrogens) medication page for healthcare professionals to search for scientific information on Pfizer medications Also find the prescribing information, announcements, resources, and channels to connect with Pfizer Medical Information --- pfizermedicalinformation com what-are-the-possible-side-effects-of-pr PREMARIN therapy should be initiated and maintained with the lowest effective dose to achieve clinical goals Female hypogonadism: 0 3 mg or 0 625 mg daily, administered cyclically (e g , three weeks on and one week off) Doses are adjusted depending on the severity of symptoms and responsiveness of the endometrium [ see Clinical Studies (14 4) ] PREMARIN® (conjugated estrogens) This product information is intended only for residents of the United States for Consumers: PREMARIN Vaginal Cream U S Patient Product Information ; PREMARIN Tablets U S Patient Product Information; for Healthcare professionals: PREMARIN Tablets U S Physician Prescribing InformationEach gram of PREMARIN (conjugated estrogens) Vaginal Cream contains 0 625 mg conjugated estrogens, USP in a nonliquefying base containing cetyl esters wax, cetyl alcohol, white wax, glyceryl monostearate, propylene glycol monostearate, methyl stearate, benzyl alcohol, sodium lauryl sulfate, glycerin, and mineral oil --- pfizermedicalinformation com premarin-vaginal-cream PREMARIN ® (conjugated estrogens) This product information is intended only for residents of the United States for Consumers: PREMARIN Vaginal Cream U S Patient Product Information ; PREMARIN Tablets U S Patient Product Information; for Healthcare professionals: PREMARIN Tablets U S Physician Prescribing Information PREMARIN® (conjugated estrogens) Warnings and Precautions 5 WARNINGS AND PRECAUTIONS 5 1 Cardiovascular Disorders An increased risk of stroke and DVT has been reported with estrogen-alone therapy An increased risk of PE, DVT, stroke and MI has been reported with estrogen plus progestin therapy Should

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