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link springer com article 10 1007 s40272-023-00600-ycantharides blister beetle, (family Meloidae), any of approximately 2,500 species of beetles (insect order Coleoptera) that secrete an irritating substance, cantharidin, which is collected mainly from Mylabris and the European species Lytta vesicatoria, commonly called Spanish fly Cantharidin is used medically as a topical skin irritant to --- dermatologyadvisor com cantharidin-podophyllin-salicylic-acid-treatme In the Middle Ages, in Europe, the dried bodies of the ‘Spanish fly’ (Lytta vesicatoria), a green, 11- to 21-mm-long beetle that can be found in certain areas of Europe and some eastern regions such as Vietnam, Taiwan, Thailand, Korea, and China, began to be used as an alleged aphrodisiac and abortifacient and in the treatment for malignant onlinelibrary wiley com doi 10 1111 cbdd 12180Cantharis vesicatoria (blister beetle) is used in Chinese medicine and has been categorized as highly toxic in the Chinese pharmacopeia In Europe, Cantharis patches have been used since ages to treat various skin-related diseases We investigated the cytotoxicity of the Cantharis ingredient, cantharidin, in 41 tumor cell lines (Oncotest panel Cantharidin is a defensive terpenoid found in blister beetles 1,2,3,4,5 Cantharidin has been investigated in many fields due to its powerful effects on treating tumors, pests control and --- nature com articles s41598-017-02393----w britannica com animal blister-beetleCombinations of CPS1 solution, cantharidin 1% podophyllotoxin 5% salicylic acid 30% (CPS2), and cantharidin 1% podophyllin 20% salicylic acid 30% (CPS3) solution are available for the treatment of warts with cure rates ranging from 64% to 100% However, even with a wide variety of treatment modalities, a safe and effective treatment with --- cellsignal com products activators-inhibitors cantharidin 70311Cantharidin, one of the active components of mylabris, is believed to have antitumor activity Cantharidin selectively inhibits protein phosphatase 2A (PP2A), which can repress multiple oncogenic Cantharidin (YCANTH™) is a proprietary drug-device combination product containing a formulation of cantharidin 0 7% topical solution (a vesicant naturally derived from blister beetles) delivered via a single-use applicator that has been developed by Verrica Pharmaceuticals Inc for the treatment of molluscum contagiosum and is also being developed for the treatment of warts In July 2023 The terpenoid Cantharidin is a natural toxin secreted by blister beetles as a defense mechanism and during egg laying Used to treat cancer for centuries in traditional Chinese medicine, Cantharidin has also been used as a putative aphrodisiac and wart remover (1) More recently, Cantharidin has been studied as a protein phosphatase inhibitor Topical cantharidin 0·7% (Ycanth) is the first treatment to be approved by the US Food and Drug Administration for the viral skin infection molluscum contagiosum Priya Venkatesan reports Molluscum contagiosum is a benign and highly contagious skin infection caused by a DNA poxvirus and characterised by small, raised lesions or papules onlinelibrary wiley com doi 10 1111 j 1349-7006 2010 01523 x--- nature com articles s41389-018-0102-2Pancreatic cancer is one of the most lethal human cancers with average 4- to 6-month survival time after diagnosis It causes about 30 000 and 40 000 annual deaths in the USA and Europe, respectively, and is currently the sixth leading cause of death due to malignant diseases in China --- sciencedirect com science article pii S0006295213007090--- thelancet com journals laninf article PIIS1473-3099(23)00583-2 fulltext